Semen Allergy

Semen Allergy may technically be called Human Seminal Plasma Hypersensitivity.

As with any substance, it’s possible to be allergic to seminal fluid. It is estimated that five percent of women are allergic to semen.

The symptoms of semen allergy can either be a localized or systemic reactions.
The localized reactions, can be an intense burning after intercourse. Some women have vaginal burning, pain, swelling, redness, or even blisters forming within 30 minutes of exposure to semen.

Others may have systemic reactions that include generalized itching, hives, angioedema, wheezing, and in very rare cases anaphylaxis. Anaphylaxis is an acute, intense reaction of the body against the allergen which may even be fatal.


Exact cause of semen allergy is not known. There is a theory that connects it to food allergies because of similar protein composition. 

Semen contains very modest quantities of the following substances: aboutonia, ascorbic acid, blood-group antigens, calcium, chlorine, cholesterol, choline, citric acid, creatine, deoxyribonucleic acid, fructose, glutathione, hyaluronidase, inositol, lactic acid, magnesium, nitrogen, phosphorus, potassium, purine, pyrimidine, pyruvic acid, sodium, sorbitol, spermidine, spermine, urea, uric acid, vitamin B12, and zinc.


There are number of diagnostic procedures available to help determine this allergy. These include some hyposensitivity tests. Another sure way to determine if a semen allergy exists is to try using condoms. If there is no reaction after intercourse on using condoms, semen allergy does exists.


Hyposensitization treatment is available for this problem. This treatment is similar to the effects of allergy shots. Your body is desensitized to the allergic effect of semen by gradually increasing the amount of semen you’re exposed to.

Meanwhile, educate your mate regarding your problem and always use a condom during sexual intercourse.

Medical Advice (Q&As) on “Semen Allergy

  1. Mary

    My labia is extremely inflamed with more than one cyst. I thought it was a really bad yeast infection. There’s burning inside and chafing and itching and on the outside. I’ve had these before and applied warm compresses and that caused it to bust but they keep returning. This time it’s really bad and it feels really hot and burning. Why do these cysts keep coming back? I’m not sexually active and I’ve been diagnosed with MS. Is it my immune system?

    1. Buddy M.D. Post author

      Any secretions down there?

      If not, your symptoms are more likely to be linked with MS. Females having MS may suffers extreme vaginal dryness. Dryness may further add up to the burning and chafing sensations.

      For this, you need to use a vaginal lubricant liberally over the area. Do not use petroleum jelly or other other cosmetic product. Special lubricants for the vaginal area, like KY jelly, need to be used.

      For nerve related symptom, like itching and burning, you may need medication. Talk to your doctor about this.


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