SSRIs Preferred Over Deanxit Due to Adverse Effects

Deanxit has many side effects. It has been banned in many countries including Denmark (the country where it was manufactured) and the U.S.

This drug is basically a combination of two psychoactive components. They are- flupentixol and melitracen. The second component (melitracen) is still not fully studied, so its use is debatable.

Side Effects of Deanxit (Flupentixol + Melitracen)

    • It may increase the heart rate. If you have a high B.P., or any other heart problem, this can be risky.
    • dizzy feeling may be there. This is because the drug causes some orthostatic hypotension.
    • Indigestion, stomach upset or vomiting sensations.
    • Many have reported sleeping problems with this drug. There may be problems with initiating sleep, having disturbed dreams, restlessness are common.
    • Drug affects the bone marrow and decreases the production of new blood cells.
    • Dryness in mouth
    • Constipation
    • Changes in appetite or weight
    • Dull headache with blurred vision

These side effects can be quite disturbing. For all these reasons, it is not one of the choicest drugs to be given.

When used, the drug is given for 6 weeks for appearance of its effects. It is prescribed in disorders with both anxiety and depressive states.

One should consider some other drug instead of Deanxit. Modern practice recommends using another class of drugs called SSRIs (Paxil, Lexapro, or Prozac) for similar disease conditions. These are safer choices. You may discuss taking them with your doctor.

In case, one is taking Deanxit due to lack of knowledge about its side effects, then at the minimum one should take the following precautions:

  • Avoid alcoholic beverages during the phase of using this drug. Alcohol has effects on our brain, and may interfere adversely with the action of this medicine.
  • Don’t drive a car or use any machinery if there is dizziness while taking Deanxit.
  • Don’t take any other antidepressant along with this drug, without informing the doctor.
  • Go for the regular medical follow-ups.

Medical Advice (Q&As) on “SSRIs Preferred Over Deanxit Due to Side Effects

  1. Sawz

    I need to ask about my patient who take this drug. He had CVD and open heart surgery 8 years ago.

    He also takes warfarin. These days he had warfarin overdose- the INR is 8.
    Any relation to deanxit?

    Reply
    1. Buddy M.D. Post author

      There is no significant documented evidence that deanxit affects INR, though studies are still going on with this drug. However, the point to remember is that deanxit should be prescribed for short durations only. It is not recommended for long term use anyway.

      Warfarin overdose is potentially a serious situation. Just be watchful if your patient is not having any other blood thinner, like aspirin, Pradaxa etc.

      Keep the INR between targeted range of 2 to 3. The value of INR = 8, that you have mentioned, is quite high. It may lead to a hemorrhagic event, if not adjusted quickly.

      Reply
  2. Manju

    I’ve used Deanxit tab for depression given for two weeks, now I stopped using it. But I’m feeling too weak in legs and arms. Kindly suggest. I’m 24 years old.

    Reply
    1. Buddy M.D. Post author

      It is not proper to stop this drug abruptly. All anti psychotic medicines are tapered off slowly.

      Why did you stop this medicine? If you still have the underlying disease for which you were taking it, it would be better to switch to some other equivalent drug (like SSRIs) than not taking any medicine.

      Your weakness may be a part of your overall illness. Discuss with your doctor about switching to some safer drug.

      Reply
  3. Rakesh

    I am using Deanxit for last 10 years and my doctor has prescribed it for me. 10 years back I was suffering from headache ( back side ). Since then, my doctor has advised to take Deanxit regularly, 0.5 mg tablet per day. And as I mentioned, from last 10 year I am using it but now I am not suffering from any kind of headache. I was NOT aware of side effects of Deanxit. Now, I am suffering from sleeping problems, disturbed dreams, restlessness, Constipation, mood disorder, dizzy feeling which were not there before. I started Deanxit 10 years back. After reading today’s news paper I found that Deanxit has been banned in India as well. You have mentioned above that Deanxit is NOT recommended for long term but now I am shocked how my doctor advised me to take this medicine for the last 10 years. You have also mentioned that it should NOT be stopped abruptly. And now its banned in India as well. Based on my above information can you please guide me the right way to get rid of all my problems? Thanks.

    Reply
    1. Buddy M.D. Post author

      Deanxit is not for long term use. Read about side effects of deanxit.

      It is suggested that you quit this medicine now. It cannot be abruptly stopped, the dose needs to be tapered over a period of two weeks.

      You may discuss with your doctor about the side effects you are facing and go ahead for leaving the drug.

      Reply
  4. Brijesh

    My father is taking deanxit for last 9 years. He has a high blood pressure problem. So, the doctor suggested him to take a deanxit once per day. Now he is suffering form the side effects of deanxit like headache and sleep disorder. Recently, after ban of deanxit in India now the doctor suggested him to take Etilaam instead of deanxit but he isn’t adjusting with this. Please sir, I request you to suggest me how to withdraw deanxit and about the Etilaam, is it good instead of the deanxit for a long time or not?

    Reply
    1. Buddy M.D. Post author

      Coping with the side effects of deanxit can be difficult. However, it is suggested to wean off from it as early as possible. This drug has turned out to be quite unsafe in a long run.

      If it is just high blood pressure, why is your father taking anti psychotic medications? Deanxit, or even etilaam are anxiolytic drugs.

      Blood pressure medications are altogether different and work differently. Read here about blood pressure medications.

      Deanxit can be replaced by etilaam, if required. However, even etilaam, which is a benzodiazapine, is not advised for a long term use. This drug has a addictive potential too.

      Reply
  5. Brijesh

    Hello sir, Thanks for your reply. We don’t know why the doctor suggested anti psychotic medications. It might be that if the mind is relax than blood pressure can be in control. Sir, can you please suggest me how my father can quit deanxit?

    Reply
    1. Buddy M.D. Post author

      It would be difficult to quit the medicine abruptly. It is suggested that you taper it.

      Since deanxit is no longer there in the market, you may switch to any SSRIs (Paxil, Lexapro, or Prozac) instead. These drugs are safer, especially in older population.

      Then, the medicine can be tapered slowly, that is reduce the dose to half for a week, then one-fourth for the next two weeks.

      You may discuss this with your doctor.

      Also, monitor your father’s blood pressure regularly. If he needs any blood pressure medication, it should be prescribed.

      Reply
  6. Sara Grey

    Hello Dr, I have been taking Zoloft for 2 months. It didn’t help me at all (last week I switched to a dose of 100mg but still no good results). How do you advise me to take it now and slowly later to not suffer from withdrawal? Thank you.

    Reply
    1. Buddy M.D. Post author

      Zoloft may take time to show results. It takes 2 to 3 months before patients say they there getting full effect of the drug.

      You may consider trying the medication for some more time.

      Reply
  7. Vineet kumar

    If deanxit/franxit is harmful for human heart, brain and bone marrow, then what is the best optional medicine for a patient who is used to take this medicine regularly.

    Reply
    1. Buddy M.D. Post author

      This would depend upon why the drug has been prescribed to you. What are your symptoms (problems)?

      For most of the depressive and anxiety states, SSRIs are preferred over deanxit. This class of medicines are much safer.

      Read more on the topic above.

      Reply
  8. Hussein J.

    I am a 23 years old male patient, with a history of asthma on ventoline. From year 2013 on June I started feeling fatigue stress tremors in hands, feeling of imbalance, sleep disturbances, anxiety and I feel dizzy. I seek medical help. I made lab studies including CBC, TSH, Vitamins, Fe and others all results were normal. Dr prescribe magnesium supplement and deanxit for short term. I didn’t feel any change and recently I suffer from the same problem, tachycardia, short of breath. I am quickly stressed from any problem occur with me. I can’t manage it. I need your help. I beg you. I visited many Dr. From different specialties cardiologist, pneumologist, endocrinologist gastroenterologist. But say you are not suffering from any thing.
    May be I am suffering from anxiety and stress.
    Note I am a BS Nursing.

    Reply
    1. Buddy M.D. Post author

      You are from a medical background and so you can well understand that anxiety can take over your body and cause physical symptoms too.

      You need to see a psychiatrist. There is no harm in taking a mild anti anxiety medication, may be a benzodiazepine, for some time.

      Reply
  9. Nina

    My mom takes deanxit for over twenty YEARS, twice a day sometimes once a day.

    Is it OK to change the med or keep taking it the same for the rest of her life?

    I heard that this med is withdrawn from several countries!

    Reply
    1. Buddy M.D. Post author

      How old is she? What were her symptoms for which this medicine was being prescribed?

      This medicine is definitely not safe. If possible, shifting to some other alternative under the supervision of a doctor is desirable.

      Reply
    1. Buddy M.D. Post author

      It has been clinically seen that it lowers sexual drive. May even cause erectile problems if used for long periods.

      Reply
  10. Arvind

    My mother has been taking Deanxit for past several years. As it has been recently banned in India, she has tried to wean herself off the drug but says that she suffers from sleeplessness in the night if she did not take the drug. Any suggestions from your side please?

    Reply
    1. Buddy M.D. Post author

      Yes, these are withdrawal symptoms of the drug. It may take 2 to 3 months for her to normalize with her sleep.

      If these effects are unmanageable, she may have to start with some other medication, may be SSRIs.

      Reply
  11. Charles

    Hi Dr. i am 36 yrs old. i have burning tonge and metalic taste in my mouth. I also have chest pain (left side of my chest) and recently stomach pain. Inadditional i started having hot flashes on my left leg. My Dr. asked me to do blood tests i.e CK, LDH,CKMB,MYO, HBDH AST etc… when the result came out my Dr. said they all came out normal. Except that only Alph-HBDH was slightly out of the range 206.39 (72-182) but that it is not clinicaly significant. That i should see a neurologist after explain these symptoms to the neurologist. The neurologist said i should do MRI inaddition that i should use Gabapentin once three times a day. So my question is Gabapentin banned in any country and why? Do i have myocardial infraction? that is been overlooked. Do i have anxiety problem because sometimes i feel very scared and i have this cold heat all over my head. What kind of neurologyia disease could i have?

    Thank you.

    Reply
      1. Charles

        Yes i have done ECG, EKG holtter and Thread mill test. They all came out normal (Negative for myocardial infraction).
        Also the MRI report says normal for Brain and Spinal cord.
        But i still have the chest pain.
        Am confused.

        Reply
        1. Buddy M.D. Post author

          Difficult to comment without actual examination. This is unlikely to be myocardial infarction. May be something related to your nerves.

          Reply

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