Deanxit (Flupentixol + Melitracen) Tablet
Deanxit is grouped under medications that are used for treating depression.
Deanxit is made up of two components- flupentixol 0.5mg (or flupenthixol, an antipsychotic) and melitracen 10mg (a tricyclic antidepressant). When mixed together, the drugs work by maximizing the effect against illness.
However, it’s not a good choice because of its potential side effects.
There are other drugs with better safety profiles which may be used instead.
Why Is Deanxit Banned in the USA?
The drug was produced in Denmark and distributed world wide. Recently, it was banned in the USA, the UK, Australia, Canada, Japan and Ireland. In addition, it was also banned in Denmark- its country of origin.
This is due to its potentially serious neurological side effects.
Flupentixol gives more side effects. And melitracen can’t be used in isolation as it gives inadequate results against illness.
Moreover, melitracen has not yet been studied fully. Essential clinical trials that need to be conducted are still due.
Intended Indications and Uses of Deanxit
As emphasized earlier, there are various other safer medications available for most of the intended applications of this drug. In any case, when used, it is given only for a short term under the supervision of a specialist doctor for the following conditions:
- Depressive illness
- Anxiety or bipolar illness. Its second component, melitracen acts against bipolar illnesses.
- Psychogenic depression
- Menopausal depression, where nothing else works
- Long lasting myogenic headache
- Resistant migraines
- Certain gastrointestinal disturbances which have a neurological component.
Usual Ways to Prescribe and Counter the Adverse Effects
One or two tablets are given daily, once in the morning and once in noon. In severe cases, the morning dose is increased to two tablets.
Deanxit takes around 2 weeks to show its action. Initial phases are uncomfortable, one may get insomnia and other side effects.
The patients gradually get used to these effects. A medication called Truxal, 15 to 30 mg, is sometimes given in the initial phase to cover side effects.
- Tachycardia or increase in the heart rate is observed in some individuals. One may feel palpitations in the chest.
- Stomach upsets, vomiting sensations
- Problems in initiating sleep.
As such, select safer alternatives. Anyhow, do not take this medication especially in these conditions:
- If you are pregnant or lactating.
- If you have any sort of cardiac insufficiency.
- If you are extremely restless or agitated.
- If you have a depressed level of consciousness.
- Severe depression that requires hospitalization or ECT.
- Don’t stop taking the drug without informing your doctor. He will supervise you in changing to other alternatives.
- Do not take any other psychoactive drug along with this medication. They may adversely interact with each other.
- Don’t take alcohol at all while you are taking this medicine.
- Be careful while driving or while handling any other machinery. Some patients have reported extreme drowsiness with this medicine, which makes you prone to accident.
- If you observe any side effect of the medication, worsening of symptoms or suicidal thoughts, report to your doctor at the earliest.
If you have taken the drug for a long time and need to withdraw it, do this carefully under the supervision of a doctor. The drug gives significant withdrawal symptoms.
It’s a habit forming drug, and does not allow easy withdrawal.
Some of the withdrawal symptoms include:
- Anxiety and panic feelings, restlessness
- Blurred vision
- Problems in balancing
- Difficulty in focusing at work
- Increased headaches
- Hallucinations and disturbing illusions
- Depression again, may be worsened
How to Withdraw?
It is therefore suggested that the withdrawal should be slow. Let it take a month.
- Try taking half the dose for one day and full the next day alternately for a week. Then reduce the drug to half and take it for the next week.
- During the third week, start skipping the medicine on each alternate day. You may then stop taking the drug altogether.
- If you get any unmanageable symptom in the process of withdrawal, report to your doctor.